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E2F TRANSCRIPTION FACTORS
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DeCS
Descriptor
English
:
E2F Transcription Factors
Descriptor
Spanish
:
Factores de Transcripción E2F
Descriptor
Portuguese
:
Fatores de Transcrição E2F
Tree Number:
D12.776.930.311
Definition
English
:
A
family
of
basic helix-loop-helix transcription factors
that
control
expression of a variety of GENES involved in
CELL CYCLE
regulation.
E2F transcription factors
typically form heterodimeric complexes with
TRANSCRIPTION FACTOR DP1
or transcription factor DP2, and they have N-terminal DNA binding and
dimerization
domains.
E2F transcription factors
can act as mediators of transcriptional repression or
transcriptional activation.
History Note
English
:
2006(1991)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
51180
Unique Identifier:
D050684
Occurrence in VHL
:
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CID-10
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